Here's a neat idea - post the chapters of your book to your blog (sound familiar?) and record each chapter as a podcast.
The book in question is hackoff.com: An Historic Murder Mystery set in the Internet Bubble and Rubble, a novel by Tom Evslin, who started posting chapters last September under a Creative Commons license.
Evslin started the podcasts last week and I've listened to a couple of episodes so far, from the first chapter. The sound quality's not terrific (a bit echo-y) but they're a great listen. I listened on my PC although I think I'd get a better experience listening on my iPod.
Incidentally, Evslin's book blog is known as a blook which, according to the Wikipedia entry, was popularized by his very book, er, blook.
Some book publishers are embracing new media like podcasting. My current favourite - The Penguin Podcast, a podcast every couple of weeks with book extracts, author interviews and features from Penguin Books UK. Innovation in book marketing.